← Cancer Research Glossary

Chimeric antigen receptor (CAR) T-cell therapy

A type of immunotherapy that genetically engineers a patient's own T cells to recognise and destroy cancer cells.

What it is

Chimeric antigen receptor (CAR) T-cell therapy is a type of treatment that uses a patient's own immune cells, called T cells, to fight cancer. To do this, doctors take a sample of the patient's T cells, modify them in a lab to recognize a specific protein on cancer cells, and then return them to the patient's body. This process is called genetic engineering.

How it works

When the modified T cells are returned to the patient's body, they can recognize and attach to cancer cells that have the specific protein they've been engineered to target. This attachment triggers the T cells to release chemicals that destroy the cancer cells. In some cases, this can lead to a reduction in cancer growth or even a complete disappearance of the cancer.

Why it matters

Understanding CAR T-cell therapy is important for patients and families affected by cancer, as it's a relatively new and promising area of research. While it's not suitable for all types of cancer, it can be a valuable treatment option for some patients who haven't responded to other therapies. Researchers are also studying CAR T-cell therapy to see if it can be used to prevent cancer from coming back.

This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional for guidance on your health.