PARP inhibitors
Drugs that block PARP enzymes, exploiting DNA repair defects in cancer cells such as those with BRCA mutations.
What it is
A PARP inhibitor is a type of medicine that blocks an enzyme called PARP. PARP enzymes help repair damaged DNA in cells. Cancer cells with certain genetic mutations, like BRCA mutations, may not be able to repair their DNA properly, and PARP inhibitors can take advantage of this weakness.
How it works
When a PARP inhibitor is taken, it blocks the PARP enzyme from working. This means that cancer cells with DNA repair defects can't fix their damaged DNA, which can eventually lead to cell death. In some cases, this can slow or stop the growth of cancer tumors.
Why it matters
Understanding PARP inhibitors is important for people with certain types of cancer, such as ovarian or breast cancer, who may be eligible for treatment with these medicines. PARP inhibitors may offer a new treatment option for patients who have tried other therapies without success. Researchers are also studying PARP inhibitors to see if they can be used in combination with other treatments to improve outcomes.
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional for guidance on your health.