PARP inhibitors
Drugs that block PARP enzymes, exploiting DNA repair defects in cancer cells such as those with BRCA mutations.
What it is
A PARP inhibitor is a type of medicine that blocks an enzyme called PARP. PARP helps repair damaged DNA in cells. When PARP is blocked, cells with faulty DNA repair systems can't fix their DNA, which can be a problem for cancer cells that have inherited genetic mutations, such as BRCA mutations.
How it works
When a cell's DNA is damaged, PARP helps fix it by temporarily stopping the cell from dividing. If PARP is blocked, the cell can't stop dividing and may die. This can be particularly effective against cancer cells that have inherited genetic mutations, such as BRCA mutations, which make it harder for them to repair their DNA.
Why it matters
Understanding PARP inhibitors is important for people with inherited genetic mutations, such as BRCA mutations, who may be at higher risk of developing certain types of cancer. These medicines may be used in combination with other treatments to help control cancer growth. Researchers are also studying PARP inhibitors to see if they can be used to treat other types of cancer.
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional for guidance on your health.