PARP inhibitors
Drugs that block PARP enzymes, exploiting DNA repair defects in cancer cells such as those with BRCA mutations.
What it is
A PARP inhibitor is a type of medication that blocks the action of PARP enzymes. PARP enzymes are proteins that help repair damaged DNA in cells. In cancer cells with certain genetic mutations, such as BRCA mutations, the DNA repair process is already faulty, and PARP inhibitors can take advantage of this weakness.
How it works
When a PARP inhibitor is taken, it blocks the PARP enzymes from repairing damaged DNA in cancer cells. This makes it harder for the cancer cells to survive and multiply. In some cases, this can lead to the death of cancer cells, slowing down the growth of the tumor.
Why it matters
Understanding PARP inhibitors is important for people with cancer, particularly those with BRCA mutations, as it may provide a new treatment option. PARP inhibitors can be used in combination with other cancer treatments to improve their effectiveness. Researchers are also studying PARP inhibitors to learn more about how they work and how they can be used to treat different types of cancer.
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional for guidance on your health.