Stereotactic radiotherapy (SBRT/SRS)

What it is

Stereotactic radiotherapy (SBRT/SRS) is a precise and targeted form of radiation therapy that delivers high doses of radiation to small tumors or lesions, typically in a few sessions. It uses advanced technology to accurately pinpoint and treat specific areas of the body, such as the brain, lungs, or prostate.

What research shows

Studies suggest that SBRT/SRS is effective in treating various types of cancer, including brain metastases, prostate cancer, and non-small cell lung cancer. Evidence indicates that SBRT/SRS can achieve high local control rates, with some studies reporting 85-98% local control rates. However, more research is needed to fully understand its long-term outcomes and potential side effects.

Current status

SBRT/SRS is a valuable treatment option for patients with small, localized tumors or lesions, particularly those who are not candidates for surgery or other treatments. However, its use is still evolving, and more research is needed to determine its optimal application and to identify potential risks and benefits.

Key studies

• PMID 42145124

  Stereotactic body radiotherapy (SBRT) is a treatment technique for localized non-small cell lung cancer, primarily used in patients who are inoperable or at high surgical risk.

  PubMed ↗
• PMID 42145123

  Stereotactic radiosurgery is now a reference treatment for small-to-medium-sized vestibular schwannomas.

  PubMed ↗
• PMID 42144019

  Stereotactic ablative body radiotherapy (SABR) is a non-invasive therapy for inoperable primary renal cell carcinoma.

  PubMed ↗
• PMID 42142536

  Inclusion of the peritumoral FLAIR-hyperintense-region (FHR) within the clinical target volume (CTV) for glioblastoma (GBM) varies across guidelines.

  PubMed ↗
• PMID 42142397

  The nonstop gated CBCT (ngCBCT) technique has been proposed as a next-generation replacement to the current inefficient clinical gated CBCT (gCBCT).

  PubMed ↗
• PMID 42141221

  Stereotactic body radiotherapy (SBRT) has emerged as a treatment option for hepatocellular carcinoma (HCC) in patients ineligible for thermal ablation or surgery.

  PubMed ↗
• PMID 42141140

  Stereotactic radiosurgery (SRS) is a commonly used alternative to whole-brain radiotherapy for patients with a limited burden of brain metastases from non-small cell lung cancer (NSCLC).

  PubMed ↗
• PMID 42140314

  Stereotactic radiosurgery (SRS) is a preferred curative modality for brain arteriovenous malformations (AVMs).

  PubMed ↗
• PMID 42139645

  External beam radiation therapy (EBRT) has gained delayed acceptance as a recommended first-line treatment modality for patients with hepatocellular carcinoma (HCC).

  PubMed ↗
• PMID 42135596

  A knowledge-based planning (KBP) pipeline was recently developed for Gamma Knife radiosurgery.

  PubMed ↗
• PMID 42134663

  The phase I Hybrid trial assessed the safety of combining simultaneous stereotactic body radiotherapy (SBRT) with concurrent cisplatin for stage III non-small cell lung cancer (NSCLC).

  PubMed ↗
• PMID 42134380

  A small-margin, MRI-guided adaptive radiotherapy approach was shown to be safe for glioblastoma patients.

  PubMed ↗
• PMID 42133905

  The optimal second-line strategy for patients with extensive-stage small cell lung cancer (ES-SCLC) developing brain-only progression (BOP) after first-line therapy remains undefined.

  PubMed ↗
• PMID 42129843

  This interim safety/toxicity analysis aims to assess toxicity of adjuvant stereotactic body radiation therapy (SBRT) after surgery of pancreatic cancer (PC) with high risk features.

  PubMed ↗