Monoclonal antibodyFDA-approvedSecond-line
Blinatumomab
How it works
Binds the CD19 and CD3 receptors, activating T cells to attack B cells.
Cancer types
Leukemia— Relapsed or refractory B-cell precursor ALL
Efficacy
In clinical trials, around 40% of CD19-positive patients achieved a complete remission, with a median progression-free survival of approximately 8 months.
Side effects
Moderate
Side effects can be significant and may require dose adjustments or supportive medication, but the treatment is usually continued.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Testing Blinatumomab in Older Patients with Acute Lymphoblastic Leukemia | Leukemia | phase-2 | — | Source → |
| Testing Combination Therapy for CD22-Positive B-Lineage Acute Lymphoblastic Leukemia | Leukemia | phase-2 | — | Source → |
| Blinatumomab Helps Adult Leukemia Patients Achieve Remission | Leukemia | phase-2 | — | Source → |
| Blinatumomab Efficacy in Children with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia | Leukemia | observational | A 1-year overall survival rate of (92.3±7.4)% was observed. | Source → |
| Shortened Blinatumomab Treatment for Children with Leukemia | Leukemia | observational | The estimated 3-year overall survival (OS) was 54%, and the relapse-free survival (RFS) was 44%. Five patients (62%) achieved CR with undetectable MRD, and all four patients who initiated treatment because of persistent MRD achieved MRD clearance (100%). | Source → |
| Chemotherapy-Free Treatment for Leukemia in Jehovah's Witness Patient | Leukemia | observational | — | Source → |
| Blinatumomab Improves Outcomes for Infants with Rare Leukemia | Leukemia | phase-3 | A 4-year disease-free survival of 83.3% versus 44.0% and a 4-year overall survival of 93.3% versus 60.2% were observed. | Source → |
| Blinatumomab Affects Different Types of T-Cells Differently | Leukemia | lab-study | — | Source → |
| Blinatumomab Efficacy and Safety in Adult B-Cell Leukemia Patients | Leukemia | observational | In the R/R B-ALL group, 11 patients achieved CR/CRh/CRi and 10 patients achieved complete MRD response. | Source → |
| Blinatumomab Improves Survival in Relapsed Leukemia Patients | Leukemia | phase-2 | 45.5% of patients achieved complete remission after 2 cycles of blinatumomab therapy. | Source → |
| Blinatumomab's Use in Pediatric B-ALL: A Review | Leukemia | review | — | Source → |
| Expert Recommendations for Blinatumomab in Pediatric B-ALL | Leukemia | review | — | Source → |
| Adding blinatumomab to leukemia treatment is safe and feasible for young adults | Leukemia | phase-2 | — | Source → |
| Blinatumomab's Role in Treating Adult Leukaemia | Leukemia | review | Blinatumomab induces a high rate of deep molecular response. | Source → |
| Immunotherapy Response Varies in B-ALL Patients | Leukemia | observational | — | Source → |
| Combination Therapy for Rare Leukemia Relapse | Leukemia | observational | — | Source → |
| Blinatumomab Shows Promise in Treating Adult Leukemia | Leukemia | observational | Of the 10 patients with relapsed/refractory B-ALL, 8 achieved complete remission (CR) and minimal residual disease (MRD) negativity after one blinatumomab treatment cycle. | Source → |
| Blinatumomab Efficacy in Pediatric B-Cell Leukemia | Leukemia | review | — | Source → |
| Blinatumomab Effective in Pediatric B-ALL Patients | Leukemia | observational | The CR rate was 81.8% in R/R and 82.5% in CR-MRD patients. | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.