Tyrosine kinase inhibitorFDA-approvedFirst-line
Dabrafenib
How it works
Blocks the BRAF V600E mutation, a genetic abnormality that drives cancer cell growth, allowing the cancer cells to die.
Cancer types
Melanoma— BRAF V600E mutation
Efficacy
In clinical trials, around 50% of patients achieved an objective response, with median progression-free survival of approximately 9.4 months.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Dabrafenib and Trametinib Rollover Study for Various Cancers | Lung Cancer | preclinical | — | Source → |
| Study Examines Treatment Options for Lung Cancer Patients with Specific Genetic Mutation | Lung Cancer | observational | Median progression-free survival was 7.5 months and median overall survival was 18.7 months in patients treated with dabrafenib and trametinib. | Source → |
| Comparing Treatments for Melanoma Patients | Melanoma | meta-analysis | Dabrafenib and trametinib improved recurrence-free survival (RFS) compared to anti-PD(L)1 therapies (hazard ratio [HR] 0.53, 95% CI, 0.40-0.70, P < .01). | Source → |
| Combining two cancer drugs may help overcome melanoma resistance | Melanoma | lab-study | — | Source → |
| Targeted Therapy Shows Promise in Treating Pediatric Melanoma | Melanoma | observational | — | Source → |
| Rare Eye Condition Linked to Cancer Treatment | Melanoma | observational | — | Source → |
| Rare Lung Cancer Patient Responds to Dabrafenib and Trametinib | Lung Cancer | observational | — | Source → |
| Neoadjuvant dabrafenib and trametinib for stage III melanoma: 5-year results | Melanoma | phase-2 | At 5 years, recurrence-free survival was 40% (95% CI 27% to 60%), distant metastasis-free survival was 57% (95% CI 42% to 76%), and overall survival was 80% (95% CI 67% to 94%). | Source → |
| Rare but Life-Threatening Side Effect of Melanoma Treatment | Melanoma | observational | — | Source → |
| Combining Medications for Advanced Melanoma Shows Promise | Melanoma | phase-2 | The confirmed objective response rate was 29.2%. | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.