ChemotherapyPhase 3 trialInvestigational
Decitabine
How it works
Interferes with DNA synthesis, preventing cancer cell growth and division.
Cancer types
Leukemia— MDS
Efficacy
In clinical trials, around 50% of patients with MDS achieved a complete or partial response.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Testing Oral Decitabine and Cedazuridine in Cancer Patients with Kidney Issues | Leukemia | phase-1 | — | Source → |
| Testing Oral Decitabine and Cedazuridine in Cancer Patients with Liver Problems | Leukemia | phase-1 | — | Source → |
| Genetically Modified T Cells and Decitabine in Treating Ovarian Cancer | Ovarian Cancer | phase-1 | — | Source → |
| Testing New Combination Therapy for Blood Cancers | Leukemia | phase-1 | — | Source → |
| Testing Combination Therapy for Advanced Leukemia | Leukemia | phase-1 | — | Source → |
| Cancer Gene Methylation Linked to Poor Prognosis in Leukemia | Leukemia | lab-study | Hypermethylation of the miR-34c CpG island correlated with shorter overall survival. | Source → |
| Researchers Identify Gene Mutation Linked to Resistance to Cancer Treatment | Leukemia | lab-study | — | Source → |
| Understanding How Decitabine Affects Cancer Cells | Leukemia | lab-study | — | Source → |
| Woman develops rare skin condition after leukemia treatment | Leukemia | observational | — | Source → |
| Elderly AML Patient Achieves Long Remission with Decitabine and Retinoic Acid | Leukemia | phase-2 | The patient attained a complete hematologic and cytogenetic remission with 3.7 years survival after 30 treatment cycles. | Source → |
| Combining Cancer Drugs May Improve Treatment for Breast and Ovarian Cancers | Ovarian Cancer | lab-study | Cell proliferation was inhibited by 48-70%, and Annexin V positivity was 42-59% in all cell lines exposed to the three-drug combinations. | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.