IDH2 inhibitorFDA-approvedFirst-line
Enasidenib
How it works
Blocks the IDH2 enzyme, which is overactive in AML cells, preventing them from multiplying.
Cancer types
Leukemia— IDH2-mutated
Efficacy
In clinical trials, around 30% of IDH2-mutated patients achieved a complete remission, with a median overall survival of approximately 5 months.
Side effects
Moderate
Side effects can be significant and may require dose adjustments or supportive medication, but the treatment is usually continued.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| New Lab Method for Measuring Cancer Drug in Human Cells | Leukemia | lab-study | — | Source → |
| Combination Therapy Shows Promise in Treating Leukaemia | Leukemia | phase-1/2 | The overall response rate was 62% (95% CI 41-80; 16 of 26) in patients with AML. | Source → |
| Enasidenib Shows Promise for Treating AML with IDH2 Mutation | Leukemia | observational | The overall response rate was 39.1% and the morphological complete remission rate was 26.1%. | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.