ChemotherapyFDA-approvedSecond-line
FOLFIRI
Generic name: irinotecan, 5-fluorouracil, leucovorin
How it works
Inhibits DNA replication in cancer cells, causing cell death. Irinotecan blocks topoisomerase I, while 5-fluorouracil and leucovorin interfere with DNA synthesis and repair.
Cancer types
Efficacy
Studies show that FOLFIRI can improve response rates and survival in patients with metastatic colorectal cancer, particularly those who have received prior chemotherapy.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Combining Nanoparticles and Medication to Boost Pancreatic Cancer Treatment | Pancreatic Cancer | animal-study | — | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.