ChemotherapyFDA-approvedFirst-line
L-asparaginase
How it works
Depletes the amino acid asparagine, which is essential for cancer cell growth, and also triggers an immune response against leukemia cells.
Cancer types
Leukemia— All patients
Efficacy
In clinical trials, around 90% of ALL patients achieved a complete remission with l-asparaginase-based therapy.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| New Nanotech Tool for Leukemia Treatment Shows Promise | Leukemia | lab-study | — | Source → |
| Understanding L-asparaginase in Leukemia Treatment | Leukemia | lab-study | — | Source → |
| New Enzyme Delivery Method for Melanoma Treatment | Melanoma | lab-study | The release time of L-ASP increased from 8 to 24 hours. | Source → |
| ASNase treatment may be less effective due to glutamate metabolism | Leukemia | lab-study | — | Source → |
| Link Between Ammonia Levels and L-Asparaginase Activity in Cancer Patients | Leukemia | lab-study | — | Source → |
| L-asparaginase's Effect on Pancreatic Cancer Linked to Glutaminase Activity | Pancreatic Cancer | lab-study | — | Source → |
| UK Paediatric Leukaemia Trials Investigate E. coli L-asparaginase | Leukemia | phase-3 | — | Source → |
| Improving L-asparaginase for Cancer Treatment | Leukemia | review | — | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.