ChemotherapyFDA-approvedSecond-line
Lonsurf
Generic name: trifluridine/tipiracil
How it works
Trifluridine is converted into 5-fluorouracil, a chemotherapy agent that interferes with DNA replication in cancer cells, causing cell death. Tipiracil inhibits the enzyme responsible for breaking down trifluridine.
Cancer types
Colorectal Cancer— All patients
Efficacy
In clinical trials, Lonsurf improved median overall survival by approximately 1.4 months compared to placebo in patients with metastatic colorectal cancer.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.