ChemotherapyFDA-approvedFirst-line
Oxaliplatin
How it works
Interferes with DNA replication and cell division, ultimately killing cancer cells, by binding to DNA and causing cross-links.
Cancer types
Colorectal Cancer— All patients
Efficacy
Studies show that oxaliplatin can improve overall survival and response rates in patients with metastatic colorectal cancer.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Testing Chemo-Immunotherapy for Pancreatic Cancer | Pancreatic Cancer | phase-2 | — | Source → |
| Testing Lung Perfusion with Oxaliplatin for Colorectal Cancer | Colorectal Cancer | phase-1 | — | Source → |
| Rectal Cancer Trial Examines New Treatment Combination | Colorectal Cancer | phase-2 | — | Source → |
| Evaluating a Combination Treatment for Metastatic Colorectal Cancer in Elderly Patients | Colorectal Cancer | phase-2 | — | Source → |
| Preventing Nerve Damage in Cancer Patients | Colorectal Cancer | preclinical | — | Source → |
| Researchers Identify New Target for Colorectal Cancer Treatment | Colorectal Cancer | lab-study | — | Source → |
| Nicotine Affects Colon Cancer Treatment Efficacy | Colorectal Cancer | lab-study | — | Source → |
| Blueberry Anthocyanins Enhance Chemotherapy Effectiveness in Colon Cancer Cells | Colorectal Cancer | lab-study | The combination of blueberry anthocyanins and oxaliplatin significantly inhibited the proliferation and colony formation of HCT116 and LOVO cells (P<0.01) and markedly suppressed tumor growth in the nude mouse xenograft model (P<0.05). | Source → |
| Oxaliplatin-resistant colorectal cancer cells linked to specific proteins | Colorectal Cancer | lab-study | Silencing CHGA and UCHL1 genes effectively suppressed the mobility and invasiveness of OXA-resistant HCT-116/OxR cells while promoting G1 phase cell cycle arrest and reducing ROS production and intracellular calcium concentrations. | Source → |
| Scientists attach cancer-fighting metal to protein to deliver it to tumors | Ovarian Cancer | lab-study | — | Source → |
| New Cancer Treatment Approach Using Moringa and 3D Printed Implants | Colorectal Cancer | lab-study | — | Source → |
| LAMA3 Gene May Help Colon Cancer Respond Better to Oxaliplatin | Colorectal Cancer | lab-study | — | Source → |
| Comparing Chemotherapy Options for Colorectal Cancer | Colorectal Cancer | phase-3 | Ox resulted in a significantly improved peritoneal recurrence-free survival in CC0/1 patients (MMC=9.0 versus Ox=12.6months, P = .01). | Source → |
| Long non-coding RNA linked to oxaliplatin resistance in colorectal cancer | Colorectal Cancer | lab-study | — | Source → |
| Oxaliplatin Side Effect Study in Colorectal Cancer Patients | Colorectal Cancer | phase-3 | — | Source → |
| New Treatment Shows Promise for Colorectal Cancer Patients | Colorectal Cancer | phase-1 | Compared with standard therapy, PIPAC-Oxaliplatin was associated with higher median good days at 6 months (181 vs 131 days; p = 0.042) and 1 year (323 vs 131 days; p = 0.032), and longer overall survival (median, 11.3 vs 5.1 months; p = 0.036). | Source → |
| Oxaliplatin Chemotherapy Less Effective in Colorectal Cancer with High WTAP Levels | Colorectal Cancer | lab-study | — | Source → |
| GL-V9 Enhances Effectiveness of Colorectal Cancer Treatment | Colorectal Cancer | lab-study | — | Source → |
| Rare Side Effect of Cancer Drug: Transient Ischemic Attack | Colorectal Cancer | observational | — | Source → |
| Combination Therapy Shows Promise Against Pancreatic Cancer | Pancreatic Cancer | lab-study | — | Source → |
| Study Examines Effectiveness of S-1 and Oxaliplatin in Treating Colorectal Liver Metastases | Colorectal Cancer | phase-2 | The disease-free survival (DFS) at 3 years was 52.9% in the low-dose group. | Source → |
| Researchers Identify Potential Biomarkers for Colorectal Cancer Resistance to Oxaliplatin | Colorectal Cancer | lab-study | — | Source → |
| Chemotherapy Sensitizes Colorectal Cancers to Immunotherapy | Colorectal Cancer | lab-study | — | Source → |
| Researchers Explore New Way to Deliver Cancer Drug | Colorectal Cancer | review | — | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.