ChemotherapyFDA-approvedInvestigational
Topotecan
How it works
Interferes with cell division, causing cancer cells to die. It works by binding to topoisomerase I, an enzyme that helps repair DNA damage.
Cancer types
Ovarian Cancer— All patients
Efficacy
Studies have shown that topotecan can improve response rates in patients with ovarian cancer.
Side effects
Moderate
Side effects can be significant and may require dose adjustments or supportive medication, but the treatment is usually continued.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Comparing BL-B01D1 to Topotecan in Recurrent Small Cell Lung Cancer | Lung Cancer | phase-3 | — | Source → |
| Testing a New Combination Therapy for Advanced Ovarian Cancer | Ovarian Cancer | phase-1 | — | Source → |
| Testing Lurbinectedin for Relapsed Small-cell Lung Cancer | Lung Cancer | phase-3 | — | Source → |
| Understanding Chemotherapy Resistance in Ovarian Cancer | Ovarian Cancer | lab-study | — | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.