ChemotherapyFDA-approvedFirst-line
Chemotherapy (e.g. Doxorubicin)
Generic name: doxorubicin
How it works
Interferes with DNA replication and cell division, causing cancer cells to die.
Cancer types
Breast Cancer— All patients
Efficacy
In clinical trials, patients with breast cancer who received chemotherapy had improved response rates and overall survival compared to those who received no treatment.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Understanding Resistance to Doxorubicin in Triple-Negative Breast Cancer | Breast Cancer | lab-study | — | Source → |
| Pegylated Liposomal Doxorubicin and Immunotherapy in Recurrent Ovarian Cancer | Ovarian Cancer | phase-2 | — | Source → |
| Detecting Cancer Drug Concentration in Cells | Breast Cancer | lab-study | — | Source → |
| Overcoming Doxorubicin Resistance in Ovarian Cancer Cells | Ovarian Cancer | lab-study | Substantial resensitization of A2780ADR cells to Doxo was achieved by verapamil (Ver). | Source → |
| Doxorubicin Resistance in Triple-Negative Breast Cancer | Breast Cancer | lab-study | — | Source → |
| Combining drugs may help fight aggressive breast cancer | Breast Cancer | lab-study | Treatment with SB431542 and doxorubicin used in combination significantly reduced cell viability (CDI 0.54-0.63) | Source → |
| New Delivery System for Colorectal Cancer Treatment | Colorectal Cancer | lab-study | The tumor suppression rate reached 42.55 ± 0.18%. | Source → |
| Long non-coding RNA STMN1P2 linked to breast cancer resistance to doxorubicin | Breast Cancer | lab-study | — | Source → |
| New Compound Shows Promise in Treating Prostate Cancer | Prostate Cancer | lab-study | — | Source → |
| Dichloroacetate Enhances Chemotherapy Effectiveness in Some Breast Cancer Cells | Breast Cancer | lab-study | The cell line MCF7 exhibited the highest rate of inhibition, followed by MDA-MB-231 and T47D. | Source → |
| Doxorubicin's kidney damage linked to SIRT1/HSF1 pathway | Ovarian Cancer | animal-study | — | Source → |
| Ovarian Cancer and Heart Damage: New Research and Treatment Strategies | Ovarian Cancer | review | — | Source → |
| Targeting Prion Protein to Overcome Chemotherapy Resistance in Lung Cancer | Lung Cancer | lab-study | — | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.