Prostate Cancer

Treatments & research overview

Best-in-class treatments in use today

For men with prostate cancer, several treatments have become standard of care. These include hormone therapy, which reduces the levels of male hormones (androgens) that fuel the growth of prostate cancer cells. One hormone therapy medication is Lutetium Lu 177 Dotatate, which is used to treat advanced prostate cancer that has spread to other parts of the body. Another hormone therapy medication is Abiraterone, which is used to treat men with advanced prostate cancer that has not responded to other treatments. Radiation therapy is another common treatment for prostate cancer. This involves using high-energy rays to kill cancer cells. One type of radiation therapy is called stereotactic body radiation therapy (SBRT), which delivers precise, high doses of radiation to the tumor. Radiation therapy can be used alone or in combination with hormone therapy. Surgery is also an option for men with prostate cancer. Radical prostatectomy, which involves removing the prostate gland, is a common surgical procedure. This can be done using traditional open surgery or more minimally invasive approaches, such as robotic-assisted surgery.

What researchers are actively studying

Researchers are actively studying several new treatments for prostate cancer. One area of focus is on targeted therapies, which aim to specifically kill cancer cells while sparing healthy cells. Researchers are testing several targeted therapies, including medications that block the activity of specific proteins involved in cancer cell growth. Another area of focus is on immunotherapy, which involves using the body's own immune system to fight cancer. Researchers are testing several immunotherapies, including medications that stimulate the immune system to attack cancer cells. Researchers are also studying new combinations of existing treatments. For example, some studies are testing the combination of hormone therapy and radiation therapy to see if this approach is more effective than either treatment alone.

Where the evidence stands

The evidence for new treatments for prostate cancer is at various stages of development. Some treatments are already approved and widely available, while others are still in the early stages of research. Approved treatments, such as hormone therapy and radiation therapy, have been extensively studied and have a strong track record of safety and effectiveness. These treatments are widely available and are often used as first-line treatments for men with prostate cancer. Clinical trials are testing several new treatments, including targeted therapies and immunotherapies. These trials are ongoing and are expected to provide more information about the safety and effectiveness of these new treatments. Early-stage research, including preclinical studies and Phase 1 trials, is also underway. These studies are exploring new biological targets and new approaches to treating prostate cancer.

What this means for people affected

The research landscape for prostate cancer is complex and rapidly evolving. There are many treatment options available, and researchers are actively studying new approaches to treating the disease. While there are many treatment options available, each man's situation is unique, and the best treatment approach will depend on the individual's specific needs and circumstances. Men with prostate cancer should work closely with their healthcare providers to determine the best course of treatment. The field of prostate cancer research is moving quickly, with new treatments and approaches being developed and tested all the time. This means that men with prostate cancer may have access to new and innovative treatments in the future.

AI-generated summary · last updated March 6, 2026

Recent research findings

Phase 2 TrialMarch 5, 2026

Trial of ESK981 for Solid Tumors

This trial is studying the effects of ESK981 in patients with certain types of solid tumors. The trial is currently recruiting participants. It's too early to know if ESK981 will be effective for these conditions.

Why it matters: This trial matters because it may help find new treatments for patients with select solid tumors.

The trial is currently recruiting and is in an early stage, so limited data is available.

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PreclinicalMarch 5, 2026

Prostate Cancer Monitoring Trial

This trial is studying the use of 18F-DCFpyL to monitor prostate cancer that has come back after treatment. The trial is currently recruiting participants. It aims to learn more about how this method works for monitoring the disease.

Why it matters: This trial matters because it could help improve the way doctors monitor prostate cancer that has returned after treatment.

The trial is currently recruiting and the phase is not specified, indicating it is in an early stage with limited data available.

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Phase 2 TrialMarch 5, 2026

Prostate Cancer Treatment Trial

This trial is studying a combination of treatments for castration-sensitive oligometastatic prostate cancer. The trial is currently active but not recruiting new participants. Researchers are exploring the effectiveness of these treatments together.

Why it matters: This trial matters because it may help find new ways to treat prostate cancer that has spread to a limited number of areas in the body.

The trial is in an early stage and not recruiting new participants, so limited data is available.

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Phase 1 TrialMarch 5, 2026

Prostate Cancer Vaccine Trial

This trial is studying a combination of a DNA vaccine and an anti-PD-1 monoclonal antibody for non-castrate recurrent oligometastatic prostate cancer. The trial is currently recruiting participants. It's too early to know if this treatment will be effective.

Why it matters: This trial matters because it explores a new potential treatment approach for a specific type of prostate cancer.

The trial is in its early stage and recruiting participants, so limited data is available.

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Phase 1 TrialMarch 5, 2026

Prostate Cancer Drug Trial

This trial is studying a new drug, AZD0516, for metastatic prostate cancer. It's looking at the drug alone and in combination with another drug, AZD9574. The trial is currently recruiting participants.

Why it matters: This trial matters because it could potentially lead to new treatment options for people with metastatic prostate cancer.

The trial is in its early stage and currently recruiting, so limited data is available.

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Phase 2 TrialMarch 5, 2026

M1774 for Refractory Prostate Cancer

This trial is studying the effect of M1774 on a type of hard-to-treat prostate cancer. The trial is currently active but not recruiting new participants. Researchers are using various tests to evaluate the treatment's effects.

Why it matters: This trial matters because it may help find new treatments for patients with refractory prostate cancer that has not responded to other therapies.

The trial is currently not recruiting new participants and is in an early stage of research.

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Phase 1 TrialMarch 5, 2026

Prostate Cancer Treatment Trial

This trial is studying treatments for advanced prostate cancer that has not responded to hormonal therapy. It is comparing different combinations of medications, including radiation and immunotherapy. The trial is currently recruiting participants.

Why it matters: This trial matters because it may help find new and more effective treatments for advanced prostate cancer.

The trial is in its early stage and currently recruiting participants, so limited data is available.

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Phase 2 TrialMarch 5, 2026

Prostate Cancer Treatment Study

This trial is studying a treatment for metastatic castration-resistant prostate cancer. The study is currently recruiting participants with varying levels of kidney function. Researchers are looking at the effects of a specific treatment on this type of cancer.

Why it matters: This trial matters because it may help find new ways to treat prostate cancer that has spread and is resistant to standard hormone therapy.

The trial is in its early stage and is still recruiting participants, so limited data is available.

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Phase 2 TrialMarch 5, 2026

Prostate Cancer Radiation Treatment Trial

This trial is studying the safety and effectiveness of a radiation-based treatment for metastatic prostate cancer with neuroendocrine cells. The trial is currently recruiting participants. The treatment being tested is Lutetium Lu 177 Dotatate.

Why it matters: This trial matters because it may help find a new treatment option for patients with metastatic prostate cancer that has neuroendocrine cells.

The trial is in its early stages and is still recruiting participants, so limited data is available.

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Phase 2 TrialMarch 5, 2026

Immunotherapy for Rare Genitourinary Tumors

This trial is studying the effectiveness of two immunotherapy drugs and one anti-cancer targeted drug for rare genitourinary tumors. The trial is currently recruiting participants. It's too early to know if this treatment will be effective.

Why it matters: This trial matters because it may lead to new treatment options for people with rare and aggressive genitourinary tumors.

The trial is still recruiting and in an early stage, so limited data is available.

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Phase 2 TrialMarch 5, 2026

Prostate Cancer Treatment Study

This trial is studying bicalutamide with or without an Akt inhibitor for previously treated prostate cancer. The trial is currently active but not recruiting new patients. Researchers are exploring the effectiveness of this combination.

Why it matters: This trial matters because it may help find new ways to treat prostate cancer that has been previously treated.

The trial is currently not recruiting new patients and is in an early stage of research.

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Phase 2 TrialMarch 4, 2026

Prostate Cancer Treatment Study

This trial is studying treatments for metastatic castration-resistant prostate cancer. It is currently active but not recruiting new patients. The trial is exploring different combinations of medications to treat this type of cancer.

Why it matters: This trial matters because it may help find new and effective treatments for patients with advanced prostate cancer.

The trial is currently not recruiting new patients and is in an early stage of research.

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Phase 1 TrialMarch 4, 2026

Prostate Cancer Trial in Japan

This trial is studying a new treatment for metastatic castration-resistant prostate cancer in Japanese participants. The trial is currently active but not recruiting new participants. Researchers are exploring the safety and effects of the treatment.

Why it matters: This trial matters because it may help find new ways to treat advanced prostate cancer.

The trial is in its early stage and not recruiting new participants, so limited data is available.

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PreclinicalMarch 2, 2026

Prostate Cancer Staging Trial

This trial is studying how well combined PSMA-PET/CT and MRI work for staging intermediate and high-risk prostate cancer. The trial is currently active but not recruiting new participants. The goal is to assess the effectiveness of this staging method.

Why it matters: This trial matters because it may help improve the accuracy of prostate cancer staging, which can inform treatment decisions.

The trial is active but not recruiting, and the phase is not specified.

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Observational StudyJanuary 1, 2026

Nerve-Sparing Surgery for Prostate Cancer

Researchers studied patients with high-risk prostate cancer who had robot-assisted surgery, looking at whether sparing nerves during surgery was safe. They found that in some cases, nerve-sparing surgery may be feasible, but the decision should be based on careful patient selection using imaging tests. The study identified factors that increase the risk of cancer returning after surgery.

Why it matters: This finding matters for patients and future research because it may help improve the balance between removing cancer and preserving patient function and quality of life.

This is an early study based on a retrospective analysis of patient data, and prospective studies are needed to validate the findings.

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