Hormone therapyFDA-approvedFirst-line
Letrozole
How it works
Blocks the production of estrogen, a hormone that fuels prostate cancer growth.
Cancer types
Breast Cancer— ER-positive
Prostate Cancer— All patients
Efficacy
Studies show that letrozole can slow disease progression and improve survival in men with advanced prostate cancer.
Side effects
Mild
Most people tolerate this treatment well. Side effects are generally manageable and do not require stopping treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Abemaciclib and Letrozole in Rare Ovarian Cancer | Ovarian Cancer | phase-2 | — | Source → |
| Study of Avutometinib, Defactinib, and Letrozole for Low-Grade Serous Ovarian Cancer | Ovarian Cancer | phase-2 | — | Source → |
| Evaluating Dalpiciclib with or without Entinostat and Letrozole in Early Breast Cancer | Breast Cancer | phase-2 | — | Source → |
| Researchers Explore New Treatment Approach for Endometrial Cancer | Ovarian Cancer | observational | — | Source → |
| Combination Therapy Shows Promise in Rare Male Breast Cancer | Breast Cancer | observational | — | Source → |
| New Delivery Method for Breast Cancer Treatment | Breast Cancer | lab-study | — | Source → |
| Combining two treatments for hormone receptor positive breast cancer | Breast Cancer | phase-2 | The estimated median progression-free survival for the combination was 17.7 months versus 14.6 months for letrozole alone. | Source → |
| CDK4/6 Inhibitors and Endocrine Therapy for Metastatic Breast Cancer | Breast Cancer | phase-3 | Ribociclib combined with letrozole significantly improved PFS over letrozole alone. | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.