ChemotherapyFDA-approvedFirst-line

Cisplatin

How it works

Damages the DNA of cancer cells, preventing them from reproducing. It also triggers an immune response against cancer cells.

Cancer types

Ovarian Cancer— All patients

Efficacy

Cisplatin has been shown to improve survival in ovarian cancer patients, with a median overall survival of approximately 30 months.

Side effects

Severe

This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.

Evidence from research

StudyCancer typeStageEfficacy
Comparing Chemotherapy Options for Lung Cancer PatientsLung Cancermeta-analysis—Source →
Cancer Cells' Metabolism Changes When Resistant to CisplatinLung Cancerlab-study—Source →
Testing Sacituzumab Govitecan and Cisplatin in Ovarian and Endometrial CancerOvarian Cancerphase-1—Source →
Artemisia Extract May Enhance Lung Cancer TreatmentLung Cancerlab-studyThe combination treatment showed a greater cytotoxic effect than either treatment alone, with a combination index (CI) of 0.7.Source →
PKM2 Inhibitors May Help Treat Cisplatin-Resistant Ovarian CancerOvarian Cancerlab-studyCombination therapy with high-dose PKM2 inhibitors and cisplatin increased apoptosis compared to controls, although the modest induction suggests apoptosis is only partially responsible for the observed effects.Source →
HDAC2 Linked to Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
JMJD5 protein may help chemotherapy work better in lung cancerLung Cancerlab-study—Source →
Cisplatin May Weaken Lung Cancer Immune ResponseLung Cancerlab-studyPretreatment with GW4869, an exosome release inhibitor, significantly enhanced cisplatin sensitivity in HCC827 cells.Source →
Comparing Chemotherapy Options for Lung Cancer PatientsLung CancerobservationalFive-year overall survival and recurrence-free survival numerically favored cisplatin (61.0% vs 48.8%, P=0.17; 63.9% vs 56.6%, P=0.12).Source →
New Treatment Combination Shows Promise for Lung CancerLung Cancerlab-study—Source →
New Biomarkers for Lung Cancer Treatment IdentifiedLung Cancerlab-study—Source →
Understanding Resistance to Ovarian Cancer TreatmentOvarian Cancerreview—Source →
Comparing Carboplatin and Cisplatin in Lung Cancer TreatmentLung Cancermeta-analysis—Source →
Ginsenoside Rg3 Enhances Cancer Treatment with CisplatinLung Cancerlab-study—Source →
USP19 and DnaJC7 May Help Cancer Treatment Work BetterOvarian Cancerlab-study—Source →
Cancer Researchers Study Re-Challenging a Patient with Platinum-Based ChemotherapyLung Cancerobservational—Source →
TRIM33 May Help Overcome Lung Cancer Resistance to CisplatinLung Cancerlab-study—Source →
Gemcitabine and Cisplatin with or without Veliparib for Advanced Pancreatic CancerPancreatic Cancerphase-2—Source →
Diosmetin Enhances Effectiveness of Cancer Treatment in Lab ExperimentsOvarian Cancerlab-study—Source →
Testing Combination Therapy for Pancreatic CancerPancreatic Cancerphase-2—Source →
Researchers Identify New Player in Lung Cancer ResistanceLung Cancerlab-study—Source →
Cancer Research Uncovers New Pathway for Cisplatin ResistanceLung Cancerlab-study—Source →
Cancer Cells May Resist Treatment Due to Body's Internal ClockLung Cancerlab-study—Source →
Cisplatin May Weaken Cancer Treatment by Boosting Immune SuppressionOvarian Cancerlab-study—Source →
MicroRNA Linked to Breast Cancer Resistance to ChemotherapyBreast Cancerlab-study—Source →
Understanding Cisplatin Resistance in Small Cell Lung CancerLung Cancerreview—Source →
Testing Cisplatin and Radiation Therapy in Advanced Triple Negative Breast CancerBreast Cancerphase-2—Source →
Researchers Identify New Target to Overcome Cisplatin Resistance in Lung CancerLung Cancerlab-study—Source →
Geniposide Enhances Cisplatin Sensitivity in Lung CancerLung Cancerlab-study—Source →
Link between gene modification and chemotherapy resistance in ovarian cancerOvarian Cancerlab-study—Source →
Ovarian Cancer Cells May Resist Treatment by Producing a Specific DNA FragmentOvarian Cancerlab-studyCisplatin showed limited efficacy in reducing tumor growth in resistant tumors.Source →
Neutrophil Traps Contribute to Ovarian Cancer Resistance to PlatinumOvarian Cancerlab-study—Source →
Combining Cisplatin and Sulforaphane May Improve Lung Cancer TreatmentLung Cancerlab-study—Source →
Tripterygium Glycosides May Help Overcome Chemotherapy Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Gene Linked to Ovarian Cancer Resistance to ChemotherapyOvarian Cancerlab-studyThe diagnostic potential of was moderate, with an area under the curve (AUC) of 0.792.Source →
Researchers Investigate Role of HMGB1 in Overcoming Cisplatin ResistanceOvarian Cancerlab-study—Source →
Cancer Cells May Resist Treatment with Help from Surrounding CellsLung Cancerlab-study—Source →
Combining Plumbagin and Cisplatin May Help Treat LeukemiaLeukemialab-studyLeukemic cells treated with cisplatin/PLB (3 μM/0.4 μM) for 24 h showed markedly reduced viability (45.51%) compared to cisplatin or PLB (81.07% or 76.36%).Source →
USP18 Plays a Role in Ovarian Cancer Cells' Resistance to CisplatinOvarian Cancerlab-study—Source →
Gene Pair Linked to Chemotherapy Response in Ovarian CancerOvarian Cancerlab-studyThe ETV4-CIC gene pair achieved the highest predictive performance for cisplatin response in ovarian cancer with an area-under-curve of 0.939.Source →
Cisplatin Treatment May Improve Lung Cancer OutcomesLung Cancerlab-studyThe disease control rate in the 24 h retention group was 92.9%, significantly higher than that in the 6 h group (92.7%) and the 1 h group (80.9%).Source →
New Compounds Show Promise in Fighting Lung CancerLung Cancerlab-studyThe benzoxazole derivatives 1a and 1b exhibited anticancer activity against A549 cells, with half-maximal inhibitory concentration (IC) values of 17.41±0.16 and 20.50±0.08 µM, respectively.Source →
ULK2 may help ovarian cancer patients respond better to chemotherapyOvarian Cancerlab-study—Source →
Using Sodium Thiosulfate to Prevent Kidney Damage in Cancer PatientsOvarian Cancerobservational—Source →
Monitoring Body Weight During Cisplatin ChemotherapyLung Cancerobservational—Source →
Macrophage Exosomes Contribute to Lung Cancer Resistance to CisplatinLung Cancerlab-study—Source →
New Tool Helps Cancer Cells Absorb ChemotherapyOvarian Cancerlab-studyIn vivo, DR-A2 significantly boosted the antitumor efficacy of cisplatin.Source →
Fruit Extract from Sausage Tree Shows Anticancer Activity in Lab ExperimentsColorectal Cancerlab-study—Source →
Evodiamine May Help Overcome Lung Cancer Resistance to CisplatinLung Cancerlab-studyThe IC-50 for A549 cells was 4 µM, and for A549 cisplatin-resistant cells, it was 2 µM.Source →
New Lung Cancer Treatment Combination Shows PromiseLung Cancerphase-2The 2-year survival rate was 88.1%, with a 3-year survival rate of 82.9%.Source →
PD-L1 Upregulation Linked to Poor Prognosis in Ovarian CancerOvarian Cancerobservational—Source →
Guiqi Yiyuan Ointment May Improve Cancer TreatmentLung Canceranimal-study—Source →
Cancer Cells Develop Resistance to CisplatinLung Cancerlab-studyTargeting FA metabolism with CPT1A inhibitors or CD36 antagonists, or blocking PARP activity, significantly reversed SART3-mediated resistance.Source →
Researchers Explore New Use for Old Cancer TherapyOvarian Cancerlab-study—Source →
Wenxia Formula Extract May Help Overcome Lung Cancer Resistance to CisplatinLung Canceranimal-study—Source →
Hydrogels May Not Improve Cisplatin's Effectiveness in Breast CancerBreast Cancermeta-analysis—Source →
Combining Traditional Chinese Medicine with Cisplatin May Help Overcome Ovarian Cancer ResistanceOvarian Cancerlab-study—Source →
GJB2 protein linked to ovarian cancer resistance to chemotherapyOvarian Cancerlab-study—Source →
HO-1 Depletion May Help Overcome Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Desensitizing Patients to Cisplatin for Ovarian Cancer TreatmentOvarian Cancerobservational—Source →
ELK3's Role in Ovarian Cancer Resistance to CisplatinOvarian Cancerlab-study—Source →
Combining Cisplatin with GSK2606414 May Help Overcome Ovarian Cancer ResistanceOvarian Cancerlab-study—Source →
Anatolian Propolis May Help Fight Ovarian CancerOvarian Cancerlab-studyThe IC value of propolis was determined as 0.342 ± 0.180 mg/mL in the A2780 cell line.Source →
New Compound May Help Overcome Lung Cancer Resistance to CisplatinLung Cancerlab-study—Source →
Combining Temozolomide and Cisplatin in Colorectal Cancer TreatmentColorectal Cancerlab-study—Source →
Combining Chemotherapy Drugs Boosts Immune Response in CancerColorectal Cancerlab-study—Source →
MMP3's Role in Ovarian Cancer Resistance to CisplatinOvarian Cancerlab-studysiRNA-mediated MMP3 knockdown significantly reduced viability, proliferation, and invasion, and these effects were further enhanced when combined with cisplatin treatment.Source →
KDM4A Gene Silencing May Help Overcome Chemotherapy Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Combining Oleanolic Acid and Cisplatin to Treat Pancreatic CancerPancreatic Cancerlab-studyThe output of analysis of the anti-proliferative and cytotoxicity effect of OA and CIS tends to show the significant inhibition of cells in a dose-dependent manner with IC value of 5.75 μM OA and 2.95 μM of CIS.Source →
Gene Linked to Chemotherapy Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
New Insight into Ovarian Cancer Resistance to TreatmentOvarian Cancerlab-study—Source →
Combining Quercetin and Cisplatin May Improve Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
PARP Inhibitors May Help Lung Cancer Patients Respond Better to ChemotherapyLung Cancerlab-study—Source →
Lung Cancer Cells May Adapt to ChemotherapyLung Cancerlab-study—Source →
Combining silica nanoparticles, cisplatin, and quercetin may help treat ovarian cancerOvarian Canceranimal-study—Source →
Ovarian Cancer Cells' Response to Cisplatin May Be Influenced by AUF1 ProteinOvarian Cancerlab-study—Source →
Combining aripiprazole with cisplatin may help treat pancreatic cancerPancreatic Cancerlab-study—Source →
Propofol May Enhance Effectiveness of Ovarian Cancer TreatmentsOvarian Cancerlab-study—Source →
New Study Compares Treatments for Rare Ovarian TumorsOvarian Cancerphase-2Median progression-free survival was 27.7 months for paclitaxel and carboplatin, and 19.7 months for bleomycin, etoposide, and cisplatin.Source →
Ovarian Cancer Biomarker Identified in Lab StudyOvarian Cancerlab-study—Source →
Cancer Research: METTL3 and circ_0000620's Role in Lung CancerLung Cancerlab-study—Source →
Combining Metformin with Cisplatin May Reduce Effectiveness in Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
Link between MUL1 gene and ovarian cancer resistance to cisplatin identifiedOvarian Cancerlab-studyPlatinum resistance increased with the upregulation of MUL1 expression (Cor = 0.5154, P = 0.02).Source →
New Targets for Overcoming Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Gene Study Identifies New Targets for Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
Long Noncoding RNA Linked to Cisplatin Resistance in Lung CancerLung Cancerlab-study—Source →
Researchers Identify Genes Linked to Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
New Way to Deliver Cancer Medicine to Colon Cancer CellsColorectal Cancerlab-studyThe organoselenium compound significantly improved cisplatin loading efficiency within the liposomes (83.4%).Source →
Gene Linked to Lung Cancer Resistance to Cisplatin IdentifiedLung Cancerlab-study—Source →
TGF-β1 and ISG20 Role in Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
Cancer Gene c-Myb Linked to Resistance to Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
Evodiamine Helps Overcome Cisplatin Resistance in Lung Cancer CellsLung Cancerlab-study—Source →
MicroRNAs Linked to Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-studyTargeting these microRNAs with oligonucleotide miRNA inhibitors reduced proliferation by more than 50% for several microRNAs.Source →
Dihydroartemisinin Enhances Cisplatin's Effect on Lung Cancer CellsLung Cancerlab-study—Source →
USP3 linked to lung cancer resistance to cisplatinLung Cancerlab-study—Source →
New Cancer-Fighting Compound Shows Promise Against Ovarian CancerOvarian Cancerlab-study—Source →
Combining two drugs may help overcome lung cancer resistanceLung Cancerlab-study—Source →
Adjuvant Therapy May Help Some Lung Cancer PatientsLung CancerobservationalThe 5-year overall survival rate was 76.1% in patients who received adjuvant therapy, compared to 50.0% in those who did not.Source →
Cisplatin's Effect on Cancer Cells Not Affected by Short-Term Autophagy InhibitionProstate Cancerlab-study—Source →
MicroRNA-486-5p May Help Overcome Cisplatin Resistance in Lung CancerLung Cancerlab-study—Source →
Ovarian Cancer Cells Show Resistance to Platinum-Based ChemotherapyOvarian Cancerlab-study—Source →
BIRC5 plays a role in ovarian cancer resistance to chemotherapyOvarian Cancerlab-studyTumors were significantly smaller in size and volume when BIRC5 was silenced.Source →
MicroRNA May Help Lung Cancer Cells Respond Better to ChemotherapyLung Cancerlab-study—Source →
Targeted Chemotherapy Delivery for Cancer TreatmentMelanomalab-studyAt the same concentration in solution, the complex was as effective as cisPt alone.Source →
Quinacrine Enhances Cisplatin's Anti-Cancer EffectivenessColorectal Cancerlab-study—Source →
TMED2 Linked to Cisplatin Resistance in Breast CancerBreast Cancerlab-study—Source →
New Cancer Treatment Combination Tested in Ovarian Cancer PatientsOvarian Cancerphase-1—Source →
LDLR's Role in Ovarian Cancer Resistance to CisplatinOvarian Cancerlab-study—Source →
New Nanodrug Delivery System May Help Overcome Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Combining selamectin with cisplatin may improve uveal melanoma treatmentMelanomalab-study—Source →
Costunolide Sensitizes Ovarian Cancer Cells to CisplatinOvarian Cancerlab-study—Source →
m6A Modification Helps Overcome Cisplatin Resistance in Lung CancerLung Cancerlab-study—Source →
Targeted Nanoparticles Help Treat Cisplatin-Resistant Ovarian CancerOvarian Cancerlab-study—Source →
Combining Cisplatin and Vinorelbine May Help Some Ovarian Cancer PatientsOvarian CancerobservationalThe objective response rate was 18.8% and the disease control rate was 75.1%.Source →
Combining Light Therapy and Chemotherapy May Help Treat Ovarian CancerOvarian Cancerlab-study—Source →
Cancer Cells React Differently to Different Cisplatin DosesColorectal Cancerlab-study—Source →
New Nanocarriers Deliver Cancer Drugs More EffectivelyBreast Cancerlab-studyNio-Cis-Dox-AL showed appropriate encapsulation efficiencies of 65.54 ± 1.25% and 80.65 ± 1.80% for Cis and Dox, respectively.Source →
Heat Therapy and Chemotherapy for Pancreatic CancerPancreatic Cancerphase-3Median post-recurrence survival was significantly prolonged in the GPH-group (15.3 versus 9.8 months; p = 0.031).Source →
Anlotinib Shows Promise Against Resistant Ovarian CancerOvarian Cancerlab-study—Source →
New Delivery System for Cancer Treatment Shows PromiseOvarian Cancerlab-studyThe combination of cisplatin and silibinin-NLCs sensitized the cisplatin-resistant A2780 OC cells and exhibited a more synergistic inhibitory effect on A2780 cells as compared with the combination of cisplatin and plain silibinin.Source →
Wentilactone A May Help Overcome Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Ovarian Cancer Cells May Resist Treatment Due to a Specific GeneOvarian Cancerlab-study—Source →
New Nanoparticles May Help Treat Cisplatin-Resistant Ovarian CancerOvarian Cancerlab-study—Source →
Anaphylactic Reaction to Carboplatin Diagnosed by Skin TestingOvarian Cancerobservational—Source →
New Compounds Show Promise in Fighting Prostate CancerProstate Cancerlab-study—Source →
Cancer Cells May Develop Resistance to Treatment by Increasing PD-L1 ExpressionLung Cancerlab-study—Source →
USP22 linked to pancreatic cancer cell resistance to treatmentPancreatic Cancerlab-study—Source →
p62 Protein Affects How Cancer Cells Respond to ChemotherapyOvarian Cancerlab-study—Source →
Overcoming Cisplatin Resistance in Ovarian CancerOvarian Cancerreview—Source →
Circular RNA may contribute to ovarian cancer resistance to chemotherapyOvarian Cancerlab-study—Source →
Pleiotrophin may affect how prostate cancer cells respond to a common chemotherapy drugProstate Cancerlab-study—Source →
Combining Peptide and Chemotherapy Shows Promise in Lung CancerLung Cancerlab-studyThe combination of 37.5 μM of CIGB-552 and 5 μM of CDDP achieved a clear synergic effect on proliferation inhibition, cell cycle arrest, apoptosis induction, and oxidative stress response.Source →
IRF-1's Role in Lung Cancer TreatmentLung Cancerlab-study—Source →
Comparing Chemotherapy Treatments for Esophageal CancerLung Cancerphase-2The overall response rate in the taxane-based group was higher than the non-taxane-based group, but was not significantly different (p=0.851).Source →
Cisplatin Boosts Immune Response in Triple-Negative Breast CancerBreast Canceranimal-study—Source →
Cancer Cells' Resistance to Chemotherapy Drug StudiedOvarian Cancerlab-study—Source →
CircRNA_101277 May Contribute to Colorectal Cancer Resistance to ChemotherapyColorectal Cancerlab-study—Source →
Combination Therapy for Esophageal Cancer Shows PromiseLeukemiaphase-3The total treatment efficiency in the study group was 86%.Source →
Researchers Test a Virus to Target Mesothelioma CellsLung Cancerlab-study—Source →
MicroRNA May Help Overcome Cisplatin Resistance in Ovarian CancerOvarian Cancerlab-study—Source →
Researchers Identify Potential Target for Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
Rare Cancer Patient Shows Complete Response to ChemotherapyPancreatic Cancerobservational—Source →
MicroRNAs may play a role in ovarian cancer treatment resistanceOvarian Cancerreview—Source →
Cancer Cells' Response to Chemotherapy May Be Influenced by SIRT3Breast Cancerlab-study—Source →
New Compound May Help Cancer Cells Respond Better to TreatmentMelanomalab-study—Source →
Hydrogel Helps Deliver Cancer Drug to Ovarian Cancer CellsOvarian Cancerlab-study—Source →
New Antibody Shows Promise Against Ovarian CancerOvarian Cancerlab-study—Source →
Ovarian Cancer Cells' Response to Cisplatin TreatmentOvarian Cancerlab-study—Source →
Combining Medications May Help Overcome Ovarian Cancer ResistanceOvarian Cancerlab-study—Source →
FGFR3 linked to ovarian cancer resistance to chemotherapyOvarian Cancerlab-study—Source →
PGC1α May Contribute to Ovarian Cancer Resistance to CisplatinOvarian Cancerlab-study—Source →
New Chemotherapy Combination Shows Promise for Ovarian Clear Cell CarcinomaOvarian Cancerphase-1Two evaluable patients showed a partial response.Source →
Curcumin Sensitizes Lung Cancer Stem Cells to CisplatinLung Cancerlab-studyCurcumin significantly suppressed colonies formation by 50%.Source →
Combining two treatments may help fight lung cancerLung Cancerlab-studyThe combination of PD-0332991 and cisplatin increased apoptosis to 7.06% in A549 cells and 7.03% in A549/CDDP cells, and G0/G1 cell cycle arrest to 9.15% in A549 cells and 49.92% in A549/CDDP cells.Source →
Long non-coding RNA linked to lung cancer resistanceLung Cancerlab-study—Source →
New Compounds Enhance Effectiveness of Platinum-Based Cancer DrugsLung Cancerlab-study—Source →
FSTL1 Protein May Help Ovarian Cancer Cells Respond to TreatmentOvarian Cancerlab-studyThe IC50 of cells treated with different concentrations of DDP was decreased after over-expressing FSTL1.Source →
Link Between Enzyme and Lung Cancer Stem Cell Resistance to ChemotherapyLung Cancerlab-study—Source →
New Compound May Help Ovarian Cancer TreatmentOvarian Cancerlab-study—Source →
How Two Cancer Drugs Affect Cells DifferentlyLung Cancerlab-study—Source →
LncRNA XIST May Help Predict Lung Cancer Resistance to CisplatinLung Cancerlab-study—Source →
MicroRNAs and Lung Cancer: A Complex Role in ChemotherapyLung Cancerreview—Source →
New Target for Lung Cancer Treatment IdentifiedLung Cancerlab-study—Source →
GLUT10's Role in Breast Cancer and Cisplatin ResistanceBreast Cancerlab-studyThe shSLC2A10#1 and shSLC2A10#2 groups exhibited increased intracellular ROS levels (relative fluorescence intensity: 1.78±0.12 and 2.05±0.15, respectively; <0.05), increased cisplatin sensitivity, reduced colony numbers, and promoted cisplatin-induced ROS accumulation and apoptosis.Source →
Low-dose dihydroartemisinin may improve lung cancer treatmentLung Cancerlab-study—Source →

This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.