ChemotherapyFDA-approvedFirst-line
Fludarabine
How it works
Interferes with DNA synthesis, causing cancer cells to die.
Cancer types
Leukemia— All patients
Efficacy
In clinical trials, around 40% of patients achieved a complete remission, with a median overall survival of approximately 18 months.
Side effects
Severe
This treatment carries a higher risk of serious side effects. Close medical monitoring is required throughout treatment.
Evidence from research
| Study | Cancer type | Stage | Efficacy | |
|---|---|---|---|---|
| Busulfan, Fludarabine, and Cyclophosphamide in Blood Cancer Treatment | Leukemia | phase-2 | — | Source → |
| Cord Blood Transplant Trial for High-Risk Hematologic Diseases | Leukemia | phase-2 | — | Source → |
| New Treatment Combination Tested in Younger Patients with Chronic Lymphocytic Leukemia | Leukemia | phase-2 | — | Source → |
| Testing Fludarabine Dosage in Children and Young Adults with B-cell Acute Lymphoblastic Leukemia | Leukemia | phase-3 | — | Source → |
| Reduced Intensity Conditioning for Adults with Acute Lymphoblastic Leukemia | Leukemia | phase-2 | — | Source → |
| Testing Imetelstat with Fludarabine and Cytarabine for Leukemia and Blood Disorders | Leukemia | phase-1 | — | Source → |
| Combining Vitamin D and Fludarabine May Help Treat Leukemia | Leukemia | lab-study | — | Source → |
| Busulfan and Fludarabine May Be Safer for Some Leukemia Patients | Leukemia | phase-3 | The 1-year transplant-related mortality was 7.2% with busulfan plus fludarabine and 14.1% with busulfan plus cyclophosphamide. | Source → |
| Rituximab Cost-Effectiveness for CLL Treatment in Brazil | Leukemia | phase-3 | — | Source → |
| Researchers Identify Potential Treatment for Aggressive Prostate Cancer | Prostate Cancer | lab-study | — | Source → |
| Combining Medications for Chronic Lymphocytic Leukemia Treatment | Leukemia | phase-2 | The overall response rate was 88.37%. | Source → |
| New Cancer Treatment Combination Shows Promise for Older Adults | Leukemia | phase-2 | The 2-year disease-free survival rate was 75.0%. | Source → |
This information is provided for general education only and is not medical advice. Always consult a qualified healthcare professional before making treatment decisions.